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Cognitive Neurology Group

Description of Research

The Cognitive Neurology team has research interests in:

•  attention and working memory

•  decision-making and action control

in healthy people and patients with stroke, Parkinson's disease and ADHD.

We want to understand how visual attention and short-term/working memory normally operate and interact, and how they might be disrupted in brain disorders. Our studies have led to new research strategies to improve inattention and working memory.

Until recently, we've focused on syndromes of visual inattention or hemispatial neglect following stroke. Now, we're applying the knowledge obtained from patients with focal lesions to other brain disorders such as Parkinson's disease (a neurodegenerative condition) and ADHD (a neurodevelopmental disorder) associated with inattention.

We're also interested in how people exert control over their actions and decisions, and how these processes are disrupted in neurological disorders. Until recently, we've focused on the role of medial frontal cortex (supplementary and pre-supplementary motor areas). Our studies of patients with focal lesions and functional imaging in healthy people have led to new theories about the contributions of these brain regions.

Now, we're applying these findings to two syndromes associated with deficits of behavioural control impulsivity and apathy that may be associated with Parkinson's disease and ADHD.

We are funded by The Wellcome Trust and MRC.

Group Leader:

Prof Masud Husain FMedSci
Wellcome Trust biography

 

Click here for:

Video of Masud interviewed on Charlie Rose Brain Series with Eric Kandel and others

 


Group Members

Dr Yee Haur - Mah
Dr Sanjay Manohar
Dr Jennifer McBride
Dr Ben Pearson
Dr Yoni Pertzov
Mrs Olga Shapeero
Dr Nihal Sinha
Miss Nahid Zokaei

 

 

 

Click here for:
  Masud Husain's lab website
  Cognitive Neurology group web page at Institute of Neurology 
  UCLH/UCL Comprehensive Biomedical Centre Neurotherapeutics theme 
  Vision at UCL

 

Selected reviews & papers:
 


Hemineglect review in Scholarpedia curated by Masud Husain

Boy F, Evans CJ, Edden RAE, Lawrence, AD, Singh KD, Husain M & Sumner P (2011) Dorsolateral Prefrontal gamma-Aminobutyric Acid in Men Predicts Individual Differences in Rash Impulsivity. Biological Psychiatry  70: 866-872.

Subramanian L, Hindle JV, Johnston S, Roberts MV, Husain M, Goebel R, Linden D (2011)  Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Treatment of Parkinson's Disease. J Neurosci 31: 16309-16317.

Husain M & Mehta MA (2011) Cognitive enhancement by drugs in health and disease. Trends in Cognitive Sciences 15: 28-36.

Gorgoraptis N, Catalao RF, Bays PM & Husain M (2011)  Dynamic Updating of Working Memory Resources for Visual Objects. J Neurosci 31: 8502-8511.

Boy F, Husain M, Sumner P (2010)  Unconscious inhibition separates two forms of cognitive control. PNAS 107: 11134-11139.

Malhotra P, Coulthard EJ & Husain M (2009)  Role of right posterior parietal cortex in maintaining attention to spatial locations over time. Brain 132: 645-660.

Singh-Curry V & Husain, M (2009)  The functional role of the inferior parietal lobe in the dorsal and ventral stream dichotomy. Neuropsychologia  47:1434-1448.

Nachev P, Kennard C & Husain M (2008) Functional role of supplementary and pre-supplementary motor areas. Nature Reviews Neuroscience 9:856-869

Bays PM & Husain M. (2008) Dynamic shifts of limited working memory resources in human vision. Science 321: 851-854.

Coulthard E, Nachev P, Husain M. (2008)
Control over conflict during movement preparation: Role of posterior parietal cortex. Neuron 58: 144-157.

Sumner P, Nachev P, Morris P, Peters AM, Jackson SR, Kennard C  & Husain M (2007) Human medial frontal cortex mediates unconscious inhibition of voluntary action. Neuron  54: 697-711.

Husain M & Nachev P (2007) Space and the parietal cortex. Trends in Cognitive Sciences 11: 30-36.

Malhotra P, Parton A, Greenwood R & Husain M (2006)
Noradrenergic modulation of space exploration in visual neglect. Annals of Neurology 59: 186-90.
 
Nachev P, Rees G, Parton A, Kennard C & Husain M (2005) Volition and conflict in human medial frontal cortex. Current Biology 15: 122-128.

Mannan S, Mort D, Hodgson T, Driver J, Kennard C & Husain M (2005) Revisiting previously searched locations in visual neglect: Role of right parietal and frontal lesions in misjudging old locations as new. Journal of Cognitive Neuroscience 17: 340-354.

Jackson S, Newport R, Mort D & Husain M (2005) Where the eye looks, the hand follows: limb-dependent magnetic misreaching in optic ataxia. Current Biology 15: 42-46.

Parton A, Malhotra & Husain M (2004) Hemispatial neglect. Journal of Neurology, Neurosurgery & Psychiatry 75: 13-21.

Bird CM, Castelli F, Malik O, Frith U & Husain (2004) The impact of extensive medial frontal damage on 'Theory of Mind' and cognition. Brain 127: 914-928.

Husain M & Rorden C (2003) Non-spatially lateralized mechanisms in hemispatial neglect. Nature Reviews Neuroscience 4:26-36.

Mort DJ, Malhotra P, Mannan SK, Rorden C, Pambakian A, Kennard C, Husain M. (2003) The anatomy of neglect. Brain 126: 1986-97.

Husain M, Parton A, Hodgson T, Mort D, Rees G (2003) Self-control during response conflict by human supplementary eye field. Nature Neuroscience 6:117-8.

Shapiro K, Hillstrom A, Husain M (2002) Control of visuotemporal attention by inferior parietal and superior temporal cortex. Current Biology 12: 1320-1325.

Husain M, Mattingley J, Driver J, Rorden C and Kennard C (2000) Dissociation of sensory and motor impairments in parietal and frontal neglect. Brain 123: 1643-1659.

Rees G, Wojciulik E, Clarke K, Husain M, Frith C and Driver J (2000) Unconscious activation of visual cortex in the damaged right hemisphere of a parietal patient with extinction. Brain 123: 1624-1633.

Mattingley JB, Husain M, Rorden C, Kennard C and Driver J (1998) Motor role of human inferior parietal lobe revealed in unilateral neglect patients. Nature 392: 179-182.

Wolpert D, Goodbody S and Husain M (1998) Maintaining internal representations: the role of the human superior parietal lobe. Nature Neuroscience 1: 529-533.

Husain M, Shapiro K, Martin, J. and Kennard C (1997) Abnormal temporal dynamics of visual attention in spatial neglect patients. Nature 385: 154-156.


For reprints please e-mail Masud Husain at m.husain@ion.ucl.ac.uk

   

 

 

This page last modified 18 October, 2013 by [ICN Web Team]

 



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